Indirect reversed-phase high-performance liquid chromatographic and direct thin-layer chromatographic enantioresolution of (R,S)-Cinacalcet.
@article{Bhushan2011IndirectRH, title={Indirect reversed-phase high-performance liquid chromatographic and direct thin-layer chromatographic enantioresolution of (R,S)-Cinacalcet.}, author={R. Bhushan and R. Dubey}, journal={Biomedical chromatography : BMC}, year={2011}, volume={25 6}, pages={ 674-9 } }
Enantioresolution of the calcimimetic drug (R,S)-Cinacalcet was achieved using both indirect and direct approaches. Six chiral variants of Marfey's reagent having L-Ala-NH(2), L-Phe-NH(2), L-Val-NH(2), L-Leu-NH(2), L-Met-NH(2) and D-Phg-NH(2) as chiral auxiliaries were used as derivatizing reagents under microwave irradiation. Derivatization conditions were optimized. Reversed-phase high-performance liquid chromatography was successful using binary mixtures of aqueous trifluoroacetic acid and… Expand
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