Indirect reversed-phase high-performance liquid chromatographic and direct thin-layer chromatographic enantioresolution of (R,S)-Cinacalcet.

@article{Bhushan2011IndirectRH,
  title={Indirect reversed-phase high-performance liquid chromatographic and direct thin-layer chromatographic enantioresolution of (R,S)-Cinacalcet.},
  author={R. Bhushan and R. Dubey},
  journal={Biomedical chromatography : BMC},
  year={2011},
  volume={25 6},
  pages={
          674-9
        }
}
Enantioresolution of the calcimimetic drug (R,S)-Cinacalcet was achieved using both indirect and direct approaches. Six chiral variants of Marfey's reagent having L-Ala-NH(2), L-Phe-NH(2), L-Val-NH(2), L-Leu-NH(2), L-Met-NH(2) and D-Phg-NH(2) as chiral auxiliaries were used as derivatizing reagents under microwave irradiation. Derivatization conditions were optimized. Reversed-phase high-performance liquid chromatography was successful using binary mixtures of aqueous trifluoroacetic acid and… Expand
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References

SHOWING 1-10 OF 29 REFERENCES
Indirect resolution of enantiomers of penicillamine by TLC and HPLC using Marfey's reagent and its variants.
  • 30
...
1
2
3
...