Indirect regulation of PTH by estrogens may require FGF23.

  title={Indirect regulation of PTH by estrogens may require FGF23.},
  author={Natalia Carrillo-L{\'o}pez and Pablo Rom{\'a}n-Garc{\'i}a and Ana Rodr{\'i}guez-Rebollar and Jos{\'e} Luis Fern{\'a}ndez-Mart{\'i}n and Manuel L Naves-D{\'i}az and Jorge B Cannata-And{\'i}a},
  journal={Journal of the American Society of Nephrology : JASN},
  volume={20 9},
The mechanisms by which estrogens modulate PTH are controversial, including whether or not estrogen receptors (ERs) are present in the parathyroid glands. To explore these mechanisms, we combined a rat model of CKD with ovariectomy and exogenous administration of estrogens. We found that estrogen treatment significantly decreased PTH mRNA and serum levels. We did not observe ERalpha or ERbeta mRNA or protein in the parathyroids, suggesting an indirect action of estrogens on PTH regulation… CONTINUE READING
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