Indirect participation of Hsp90 in the regulation of the cyclin E turnover.


Cyclin E is the Cdk2-regulatory subunit required for the initiation of DNA replication at the G1/S transition. It accumulates in late G1 phase and gets rapidly degraded by the ubiquitin/proteasome pathway during S phase. The degradation of cyclin E is a consequence of its phosphorylation and subsequent isomerization by the peptidyl-prolyl isomerase Pin1. We… (More)
DOI: 10.1016/j.bcp.2008.09.038

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