Indirect inhibition by bradykinin of cyclic AMP generation in isolated rat glomeruli and mesangial cells.

@article{Bascands1993IndirectIB,
  title={Indirect inhibition by bradykinin of cyclic AMP generation in isolated rat glomeruli and mesangial cells.},
  author={Jean-Loup Bascands and Christiane P{\^e}cher and J. P. Girolami},
  journal={Molecular pharmacology},
  year={1993},
  volume={44 4},
  pages={818-26}
}
The present study was designed to evaluate the effect of the activation of bradykinin (BK) receptors on intracellular cAMP levels in isolated glomeruli as well as in cultured rat mesangial cells. BK affected basal cAMP content only in the presence of the phosphodiesterase inhibitor isobutylmethylxanthine. Furthermore, BK inhibited forskolin-, prostaglandin E2-, and isoproterenol-stimulated cAMP accumulation, both in the presence and in the absence of isobutylmethylxanthine. The inhibitory… CONTINUE READING