Indirect evidence of transposon-mediated selection of antibiotic resistance genes in aquatic systems at low-level oxytetracycline exposures.

@article{Knapp2008IndirectEO,
  title={Indirect evidence of transposon-mediated selection of antibiotic resistance genes in aquatic systems at low-level oxytetracycline exposures.},
  author={Charles W. Knapp and Christina A Engemann and Mark L. Hanson and Patricia L. Keen and Kenneth J Hall and David W. Graham},
  journal={Environmental science & technology},
  year={2008},
  volume={42 14},
  pages={5348-53}
}
Subinhibitory levels of antibiotics can promote the development of antibiotic resistance in bacteria. However, it is unclear whether antibiotic concentrations released into aquatic systems exert adequate pressure to select populations with resistance traits. To examine this issue, 15 mesocosms containing pristine surface water were treated with oxytetracycline (OTC) for 56 days at five levels (0, 5, 20, 50, and 250 microg L(-1)), and six tetracycline-resistance genes (tet(B), tet(L), tet(M… CONTINUE READING