Indirect evidence for nitric oxide involvement in multiple sclerosis by characterization of circulating antibodies directed against conjugated S-nitrosocysteine.

@article{Boullerne1995IndirectEF,
  title={Indirect evidence for nitric oxide involvement in multiple sclerosis by characterization of circulating antibodies directed against conjugated S-nitrosocysteine.},
  author={Anne Isabelle Boullerne and Klaus G. Petry and M. Meynard and Michel Geffard},
  journal={Journal of neuroimmunology},
  year={1995},
  volume={60 1-2},
  pages={117-24}
}
Converging data suggest that nitric oxide (NO) production by cytokine-induced immune cells in demyelinating lesions is involved in multiple sclerosis (MS). High levels of NO may complex to suitable amino acids, causing an immune response against the formed neo-epitopes. By testing MS sera with chemically defined nitroso-amino acids conjugated to carrier protein in ELISA, we observed a significant antibody reaction against the S-nitroso-cysteine epitope. The MS antibody response was exclusively… CONTINUE READING

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