Indirect estimation of the area density of Atg8 on the phagophore.

@article{Xie2009IndirectEO,
  title={Indirect estimation of the area density of Atg8 on the phagophore.},
  author={Zhiping Xie and Usha Nair and Jiefei Geng and Maciej B. Szefler and Edward D. Rothman and Daniel J. Klionsky},
  journal={Autophagy},
  year={2009},
  volume={5 2},
  pages={
          217-20
        }
}
  • Zhiping Xie, Usha Nair, +3 authors Daniel J. Klionsky
  • Published in Autophagy 2009
  • Biology, Medicine
  • Atg8 is a ubiquitin-like protein that controls the expansion of the phagophore during autophagosome formation. It is recruited to the phagophore during the expansion stage and released upon the completion of the autophagosome. One possible model explaining the function of Atg8 is that it acts as an adaptor of a coat complex. Here, we tested the coat-adaptor model by estimating the area density of Atg8 molecules on the phagophore. We developed a computational process to simulate the random… CONTINUE READING

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