Indirect application of near infrared light induces neuroprotection in a mouse model of parkinsonism - an abscopal neuroprotective effect.

@article{Johnstone2014IndirectAO,
  title={Indirect application of near infrared light induces neuroprotection in a mouse model of parkinsonism - an abscopal neuroprotective effect.},
  author={Daniel M Johnstone and Nabil El Massri and Cecile Moro and Sharon Spana and X S Wang and Napoleon Torres and C. Chabrol and Xavier De Jaeger and Florian Reinhart and Sivaraman Purushothuman and A. L. Benabid and Jonathan R. Stone and John Mitrofanis},
  journal={Neuroscience},
  year={2014},
  volume={274},
  pages={93-101}
}
We have previously shown near infrared light (NIr), directed transcranially, mitigates the loss of dopaminergic cells in MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)-treated mice, a model of parkinsonism. These findings complement others suggesting NIr treatment protects against damage from various insults. However one puzzling feature of NIr treatment is that unilateral exposure can lead to a bilateral healing response, suggesting NIr may have 'indirect' protective effects. We… CONTINUE READING