Indirect activation of naïve CD4+ T cells by dendritic cell–derived exosomes

@article{Thry2002IndirectAO,
  title={Indirect activation of na{\"i}ve CD4+ T cells by dendritic cell–derived exosomes},
  author={Clotilde Th{\'e}ry and Livine Annie Alice Duban and Elodie Segura and Philippe V{\'e}ron and Olivier Lantz and S{\'e}bastian Amigorena},
  journal={Nature Immunology},
  year={2002},
  volume={3},
  pages={1156-1162}
}
Dendritic cells (DCs) secrete vesicles of endosomal origin, called exosomes, that bear major histocompatibility complex (MHC) and T cell costimulatory molecules. Here, we found that injection of antigen- or peptide-bearing exosomes induced antigen-specific naïve CD4+ T cell activation in vivo. In vitro, exosomes did not induce antigen-dependent T cell stimulation unless mature CD8α− DCs were also present in the cultures. These mature DCs could be MHC class II–negative, but had to bear CD80 and… CONTINUE READING
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