Indinavir protein-free concentrations when used in indinavir/ritonavir combination therapy.

Abstract

OBJECTIVE To describe the in vivo protein-binding characteristics of indinavir (IDV) in the presence of ritonavir (RTV) relative to total IDV plasma concentrations. DESIGN The ACTG protocol 5055 was a multicenter study comparing the safety and pharmacokinetics of IDV/RTV at doses of 800/200 and 400/400 mg twice daily in HIV-infected adults. METHODS… (More)

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Cite this paper

@article{King2005IndinavirPC, title={Indinavir protein-free concentrations when used in indinavir/ritonavir combination therapy.}, author={Jennifer Renae King and John G. Gerber and Courtney V Fletcher and Lane Bushman and Edward P. Acosta}, journal={AIDS}, year={2005}, volume={19 10}, pages={1059-63} }