Indinavir concentrations and St John's wort

  title={Indinavir concentrations and St John's wort},
  author={Stephen C. Piscitelli and Aaron H. Burstein and Doreen G. Chaitt and Raul M. Alfaro and Judith Falloon},
  journal={The Lancet},
Lack of effect of St John's Wort on carbamazepine pharmacokinetics in healthy volunteers
Reductions in concentrations of CYP3A4 substrates indinavir and cyclosporine associated with St John's Wort are described.
Effect of St John's wort on the pharmacokinetics of fexofenadine
The effect of St John's wort on P‐glycoprotein activity in vivo was examined with use of fexofenadine as selective probe drug.
Drug interaction between St John’s wort and zolpidem in healthy subjects
St John’s wort is one of the most commonly used herbal antidepressants for treatment of mild to moderate depression and its effect on the pharmacokinetics of zolpidem in healthy subjects is investigated.
Effects of St John's wort and CYP2C9 genotype on the pharmacokinetics and pharmacodynamics of gliclazide
The aim of this study was to assess potential pharmacokinetic and pharmacodynamic interactions between St John's wort and gliclazide in healthy subjects with different cytochrome P450 2C9 (CYP2C9) genotypes.
St John's Wort induces intestinal P‐glycoprotein/MDR1 and intestinal and hepatic CYP3A4
Recently, St John's Wort was reported to substantially decrease blood/plasma concentrations and efficacy of cyclosporine (INN, ciclosporin), indinavir, and digoxin.
Different effects of St John's Wort on the pharmacokinetics of simvastatin and pravastatin
St. John's Wort and Drug Interactions
Although extracts of St. John's wort (Hypericum perforatum) are safe and may be effective for the treatment of moderately depressed patients, 3 recent studies have suggested that these extracts should not be used in clinical practice.
St John's wort modulation and developmental expression of multidrug transporters in the rat
Extracts of St John's wort are a potent inducer of enzymes of the cytochrome P450 system and of the transport protein P‐glycoprotein, and interactions with a range of commonly prescribed medications have been described.


Determination of indinavir, a HIV-1 protease inhibitor, in human plasma using ion-pair reversed-phase high-performance liquid chromatography.
Three potential uses of indinavir monitoring are illustrated: to assess individual dosing regimen, to assess patient compliance, and to monitor unusual indinavIR levels caused by changed drug clearance.
HIV Drug Resistance and Insufficient Drug Plasma Levels as Factors Determining Antiretroviral Treatment Failure
There are a lot of unresolved issues, but the combination of resistance testing and therapeutic drug monitoring is the first step toward a global approach of HIV treatment taking into account the right drug at the appropriate concentration.
HIV-protease inhibitors.
  • C. Flexner
  • Biology
    The New England journal of medicine
  • 1998
Inhibitors of human immunodeficiency virus (HIV)–encoded protease, combined with nucleoside analogues with antiretroviral activity, cause profound and sustained suppression of viral replication,