Indigo naturalis upregulates claudin-1 expression in human keratinocytes and psoriatic lesions.

@article{Lin2013IndigoNU,
  title={Indigo naturalis upregulates claudin-1 expression in human keratinocytes and psoriatic lesions.},
  author={Y P Lin and Hsiao-Wen Chen and Yann-Lii Leu and Yueh-lung Yang and Yu Fang and Jong-Hwei Su Pang and Tsong-Long Hwang},
  journal={Journal of ethnopharmacology},
  year={2013},
  volume={145 2},
  pages={614-20}
}
ETHNOPHARMACOLOGICAL RELEVANCE Indigo naturalis is used in traditional Chinese medicine to treat various dermatoses. Our previous clinical studies showed that indigo naturalis is an effective treatment for psoriasis. Herein, the capabilities of indigo naturalis extract and its derivatives to increase claudin-1 expression and tight junction (TJ) function in human keratinocytes and psoriatic lesions were further studied. MATERIALS AND METHODS Claudin-1 expression in psoriatic plaques with or… CONTINUE READING
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