Indigenous microfloras and resistance to bacterial infection in mice with experimentally induced diabetes: a possible animal model for opportunistic infection.

@article{Imai1984IndigenousMA,
  title={Indigenous microfloras and resistance to bacterial infection in mice with experimentally induced diabetes: a possible animal model for opportunistic infection.},
  author={A Imai and Kazuhiko Morishita and Y Kurihara},
  journal={Canadian journal of microbiology},
  year={1984},
  volume={30 2},
  pages={
          186-91
        }
}
Persistent diabetes was induced in male Slc:ddY mice by a single intraperitoneal injection of 200 mg/kg streptozotocin (STZ). In these mice, the numbers of aerobic gram-negative bacilli, staphylococci (including micrococci), and streptococci increased, while those of other bacteria were almost unchanged in both oral and caecal floras. The mice were vulnerable to oral infection of Salmonella enteritidis, intranasal infection of Klebsiella pneumoniae and Serratia marcescens, and contact infection… 
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Biological Models in Radiopharmaceutical Development
TLDR
This work describes the design of Candidate Radiopharmaceuticals, and the selection of Biological Models, for drug development and Moral and Ethical Considerations, as well as principles and training programs for research with Animals.

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