Indigenous enteric eosinophils control DCs to initiate a primary Th2 immune response in vivo

  title={Indigenous enteric eosinophils control DCs to initiate a primary Th2 immune response in vivo},
  author={Derek K Chu and R Jim{\'e}nez-Saiz and Christopher P. Verschoor and Tina D. Walker and Susanna I Goncharova and Alba Llop-Guevara and Pamela Shen and Melissa E. Gordon and Nicole G Barra and Jennifer D. Bassett and Joshua Kong and Ramzi Fattouh and Kathy D McCoy and Dawn M. E. Bowdish and Jonas S Erjef{\"a}lt and Oliver Pabst and Alison A. Humbles and Roland Kolbeck and Susan Waserman and Manel Jordana},
  booktitle={The Journal of experimental medicine},
Eosinophils natively inhabit the small intestine, but a functional role for them there has remained elusive. Here, we show that eosinophil-deficient mice were protected from induction of Th2-mediated peanut food allergy and anaphylaxis, and Th2 priming was restored by reconstitution with il4(+/+) or il4(-/-) eosinophils. Eosinophils controlled CD103(+) dendritic cell (DC) activation and migration from the intestine to draining lymph nodes, events necessary for Th2 priming. Eosinophil activation… CONTINUE READING
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