Indigenous enteric eosinophils control DCs to initiate a primary Th2 immune response in vivo

@inproceedings{Chu2014IndigenousEE,
  title={Indigenous enteric eosinophils control DCs to initiate a primary Th2 immune response in vivo},
  author={Derek K Chu and R Jim{\'e}nez-Saiz and Christopher P. Verschoor and Tina D. Walker and Susanna I Goncharova and Alba Llop-Guevara and Pamela Shen and Melissa E. Gordon and Nicole G Barra and Jennifer D. Bassett and Joshua Kong and Ramzi Fattouh and Kathy D McCoy and Dawn M. E. Bowdish and Jonas S Erjef{\"a}lt and Oliver Pabst and Alison A. Humbles and Roland Kolbeck and Susan Waserman and Manel Jordana},
  booktitle={The Journal of experimental medicine},
  year={2014}
}
Eosinophils natively inhabit the small intestine, but a functional role for them there has remained elusive. Here, we show that eosinophil-deficient mice were protected from induction of Th2-mediated peanut food allergy and anaphylaxis, and Th2 priming was restored by reconstitution with il4(+/+) or il4(-/-) eosinophils. Eosinophils controlled CD103(+) dendritic cell (DC) activation and migration from the intestine to draining lymph nodes, events necessary for Th2 priming. Eosinophil activation… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 15 times over the past 90 days. VIEW TWEETS
22 Citations
79 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 79 references

Similar Papers

Loading similar papers…