Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis

  title={Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis},
  author={Jessica M. Yano and Kristie Yu and G P Donaldson and Gauri G. Shastri and Phoebe Ann and Liang Ma and Cathryn R Nagler and Rustem F Ismagilov and S K Mazmanian and Elaine Y. Hsiao},
The gastrointestinal (GI) tract contains much of the body's serotonin (5-hydroxytryptamine, 5-HT), but mechanisms controlling the metabolism of gut-derived 5-HT remain unclear. Here, we demonstrate that the microbiota plays a critical role in regulating host 5-HT. Indigenous spore-forming bacteria (Sp) from the mouse and human microbiota promote 5-HT biosynthesis from colonic enterochromaffin cells (ECs), which supply 5-HT to the mucosa, lumen, and circulating platelets. Importantly, microbiota… CONTINUE READING
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