Indices of brain beta-adrenergic receptor signal transduction in the learned helplessness animal model of depression.

Abstract

Both stress response and antidepressant drug action may be mediated by beta-adrenergic receptors (beta AR). Since learned helplessness is a stress-induced animal model of depression, beta AR are relevant to investigate in this model. To date, studies have measured changes in total receptor density (RT), but have not examined more detailed aspects of signal… (More)

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@article{Gurguis1996IndicesOB, title={Indices of brain beta-adrenergic receptor signal transduction in the learned helplessness animal model of depression.}, author={George N. M. Gurguis and Gerald L. Kramer and Frederick D Petty}, journal={Journal of psychiatric research}, year={1996}, volume={30 2}, pages={135-46} }