Indian hedgehog signaling pathway: expression and regulation in pancreatic cancer.

@article{Kayed2004IndianHS,
  title={Indian hedgehog signaling pathway: expression and regulation in pancreatic cancer.},
  author={Hany Kayed and Joerg Kleeff and Shereen Keleg and Junchau Guo and Knut Ketterer and Pascal O. Berberat and Nathalia A. Giese and Irene Esposito and Thomas Giese and Markus W. B{\"u}chler and Helmut Friess},
  journal={International journal of cancer},
  year={2004},
  volume={110 5},
  pages={668-76}
}
Pancreatic cancer is an aggressive malignancy that exhibits a number of genetic and epigenetic alterations. Indian hedgehog (Ihh) and its 2 signaling receptors, patched (Ptc) and smoothened (Smo), are involved in pancreatic development and regulation of beta-cell function as well as in certain human tumors. In the current study, we analyzed the expression, distribution and function of Ihh and its receptors in pancreatic cancer. Quantitative RT-PCR and immunohistochemistry were utilized to… CONTINUE READING

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