Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development.

  title={Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development.},
  author={Ung-il Chung and Ernestina Schipani and Andrew P. McMahon and Henry M. Kronenberg},
  journal={The Journal of clinical investigation},
  volume={107 3},
Vertebrate skeletogenesis requires a well-coordinated transition from chondrogenesis to osteogenesis. Hypertrophic chondrocytes in the growth plate play a pivotal role in this transition. Parathyroid hormone-related peptide (PTHrP), synthesized in the periarticular growth plate, regulates the site at which hypertrophy occurs. By comparing PTH/PTHrP receptor(-/-)/wild-type (PPR(-/-)/wild-type) chimeric mice with IHH(-/-);PPR(-/-)/wild-type chimeric and IHH(-/-)/wild-type chimeric mice, we… CONTINUE READING


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