Indian Hedgehog signalling triggers Nkx3.2 protein degradation during chondrocyte maturation.


The Ihh (Indian Hedgehog) pathway plays an essential role in facilitating chondrocyte hypertrophy and bone formation during skeletal development. Nkx3.2 (NK3 homeobox 2) is initially induced in chondrocyte precursor cells, maintained in early-stage chondrocytes and down-regulated in terminal-stage chondrocytes. Consistent with these expression patterns… (More)
DOI: 10.1042/BJ20112062