Indexation as a novel mechanism of lymphocyte homeostasis: the number of CD4+CD25+ regulatory T cells is indexed to the number of IL-2-producing cells.

@article{Almeida2006IndexationAA,
  title={Indexation as a novel mechanism of lymphocyte homeostasis: the number of CD4+CD25+ regulatory T cells is indexed to the number of IL-2-producing cells.},
  author={Afonso R. M. Almeida and Bruno Zaragoza and Ant{\^o}nio Albano de Freitas},
  journal={Journal of immunology},
  year={2006},
  volume={177 1},
  pages={
          192-200
        }
}
To fulfill its mission, the immune system must maintain a complete set of different cellular subpopulations that play specific roles in immune responses. We have investigated the mechanisms regulating CD4+CD25+ regulatory T (Treg) cell homeostasis. We show that the expression of the high-affinity IL-2Ralpha endows these cells with the capacity to explore the IL-2 resource, ensuring their presence while keeping their number tied to the number of CD4+ T cells that produce IL-2. We show that such… CONTINUE READING

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