Index switching causes “ spreading-of-signal ” among multiplexed samples in Illumina HiSeq 4000 DNA sequencing

@inproceedings{Sinha2017IndexSC,
  title={Index switching causes “ spreading-of-signal ” among multiplexed samples in Illumina HiSeq 4000 DNA sequencing},
  author={Rahul Sinha and Geoff Stanley and Gunsagar S Gulati and Camille Ezran and Kyle J. Travaglini and {\'E}ric and Wei and Charles K. F. Chan and Ahmad N Nabhan and Tianying Su and R. Morand S. Morganti and Dudonne Stephanie and Conley and Hassan Chaib and Kristy Red-Horse and Michael Thornton Longaker and Michael P. Snyder and Aparna Mark and Krasnow and Irving L Weissman},
  year={2017}
}
Illumina-based next generation sequencing (NGS) has accelerated biomedical discovery through its ability to generate thousands of gigabases of sequencing output per run at a fraction of the time and cost of conventional technologies. The process typically involves four basic steps: library preparation, cluster generation, sequencing, and data analysis. In 2015, a new chemistry of cluster generation was introduced in the newer Illumina machines (HiSeq 3000/4000/X Ten) called exclusion… CONTINUE READING

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