Independent roles of perforin, granzymes, and Fas in the control of Friend retrovirus infection.

@article{Zelinskyy2004IndependentRO,
  title={Independent roles of perforin, granzymes, and Fas in the control of Friend retrovirus infection.},
  author={Gennadiy Zelinskyy and Sandra Balkow and Simone Schimmer and K. Schepers and Markus Michael Simon and Ulf Dittmer},
  journal={Virology},
  year={2004},
  volume={330 2},
  pages={365-74}
}
Cytotoxic T-cells (CTL) play a central role in the recovery of mammalian hosts from retroviral infections. However, the molecular pathways that mediate the antiretroviral activity of CTL are still elusive. Here we explore the protective role of the two main cytolytic pathways of CTL, that is, granule exocytosis and Fas/Fas ligand (FasL), in acute and persistent Friend retrovirus (FV) infection of mice. For this purpose, we have used mutant mouse strains with targeted gene defects in one or more… CONTINUE READING

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