Independent roles of apical membrane antigen 1 and rhoptry neck proteins during host cell invasion by apicomplexa.

@article{Giovannini2011IndependentRO,
  title={Independent roles of apical membrane antigen 1 and rhoptry neck proteins during host cell invasion by apicomplexa.},
  author={Donatella Giovannini and Stephan Stanislaw Sp{\"a}th and C{\'e}line Lacroix and Audrey Perazzi and Daniel Youssef Bargieri and Vanessa Lagal and Camille Lebugle and Audrey Combe and Sabine Thiberge and Patricia Baldacci and Isabelle Tardieux and Robert M{\'e}nard},
  journal={Cell host & microbe},
  year={2011},
  volume={10 6},
  pages={
          591-602
        }
}
  • Donatella Giovannini, Stephan Stanislaw Späth, +9 authors Robert Ménard
  • Published in Cell host & microbe 2011
  • Biology, Medicine
  • During invasion, apicomplexan parasites form an intimate circumferential contact with the host cell, the tight junction (TJ), through which they actively glide. The TJ, which links the parasite motor to the host cell cytoskeleton, is thought to be composed of interacting apical membrane antigen 1 (AMA1) and rhoptry neck (RON) proteins. Here we find that, in Plasmodium berghei, while both AMA1 and RON4 are important for merozoite invasion of erythrocytes, only RON4 is required for sporozoite… CONTINUE READING

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