Independent repression of a GC-rich housekeeping gene by Sp1 and MAZ involves the same cis-elements.

@article{Song2001IndependentRO,
  title={Independent repression of a GC-rich housekeeping gene by Sp1 and MAZ involves the same cis-elements.},
  author={Jun Kyung Song and Hideyo Ugai and Ichiro Kanazawa and Ka-wai Sun and Kazunari K Yokoyama},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 23},
  pages={19897-904}
}
The transcription factors Sp1 and MAZ (Myc-associated zinc finger protein) contain several zinc finger motifs, and each functions as both a positive and a negative regulator of gene expression. In this study, we characterized the extremely GC-rich promoter of the human gene for MAZ, which is known as a housekeeping gene. Unique symmetrical motifs in the promoter region (nucleotides -383 to -334) were essential for the expression of the gene for MAZ, whereas an upstream silencer element… CONTINUE READING
17 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 17 extracted citations

Similar Papers

Loading similar papers…