Independent regulation of tumor cell migration by matrix stiffness and confinement.

@article{Pathak2012IndependentRO,
  title={Independent regulation of tumor cell migration by matrix stiffness and confinement.},
  author={Amit Kumar Pathak and S. Kiran Kumar},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 26},
  pages={10334-9}
}
Tumor invasion and metastasis are strongly regulated by biophysical interactions between tumor cells and the extracellular matrix (ECM). While the influence of ECM stiffness on cell migration, adhesion, and contractility has been extensively studied in 2D culture, extension of this concept to 3D cultures that more closely resemble tissue has proven challenging, because perturbations that change matrix stiffness often concurrently change cellular confinement. This coupling is particularly… CONTINUE READING
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