Independent prognostic role of p16 expression in lung cancer.


OBJECTIVES The cyclin-dependent kinase p16 (also known as Ink4A, Mts1, Cdkn2, and Cdkn4i) has been proposed as a tumor suppressor gene mapped on chromosome segment 9p21. This study evaluated p16 protein expression in 135 lung cancer specimens and investigated potential genetic alterations occurring in this gene. RESULTS We found altered p16… (More)


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@article{Grger1999IndependentPR, title={Independent prognostic role of p16 expression in lung cancer.}, author={Angela Maria Gr{\"{o}ger and Mario Caputi and Vincenzo Esposito and Andrea De Luca and Luigi Bagella and C Pacilio and Walter Klepetko and Giovan Giacomo Giordano and Feliciano Baldi and Hans E. Kaiser and Ernest Wolner and Alessandro Giordano}, journal={The Journal of thoracic and cardiovascular surgery}, year={1999}, volume={118 3}, pages={529-35} }