Independent origins of loss-of-function mutations conferring oxamniquine resistance in a Brazilian schistosome population.

Abstract

Molecular surveillance provides a powerful approach to monitoring the resistance status of parasite populations in the field and for understanding resistance evolution. Oxamniquine was used to treat Brazilian schistosomiasis patients (mid-1970s to mid-2000s) and several cases of parasite infections resistant to treatment were recorded. The gene underlying… (More)
DOI: 10.1016/j.ijpara.2016.03.006

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