Independent neuronal oscillators of the rat globus pallidus.

  title={Independent neuronal oscillators of the rat globus pallidus.},
  author={I M Stanford},
  journal={Journal of neurophysiology},
  volume={89 3},
In vivo, neurons of the globus pallidus (GP) and subthalamic nucleus (STN) resonate independently around 70 Hz. However, on the loss of dopamine as in Parkinson's disease, there is a switch to a lower frequency of firing with increased bursting and synchronization of activity. In vitro, type A neurons of the GP, identified by the presence of I(h) and rebound depolarizations, fire at frequencies (<or=80 Hz) in response to glutamate pressure ejection, designed to mimic STN input. The profile of… CONTINUE READING