Independent mutations of the human CD3-epsilon gene resulting in a T cell receptor/CD3 complex immunodeficiency.

@article{Soudais1993IndependentMO,
  title={Independent mutations of the human CD3-epsilon gene resulting in a T cell receptor/CD3 complex immunodeficiency.},
  author={Claire Soudais and Jean-Pierre de Villartay and Françoise le Deist and Alain Fischer and Barbara Lisowska-Grospierre},
  journal={Nature genetics},
  year={1993},
  volume={3 1},
  pages={77-81}
}
The T-cell receptor (TCR) is composed of two glycoproteins (alpha and beta or gamma and delta) associated with four invariant polypeptides (CD3-gamma, delta, epsilon and zeta). The majority of TCR/CD3 complexes contain six polypeptide chains, and although there is some flexibility in the complex subunit stoichiometry the CD3-epsilon chain is central to CD3 core assembly and full complex formation. We have described previously defective expression of the TCR/CD3 complex in an immunodeficient… CONTINUE READING

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