Independent measures of insulin secretion and insulin sensitivity during the same test: the glucagon-insulin tolerance test.

@article{Alvarsson2008IndependentMO,
  title={Independent measures of insulin secretion and insulin sensitivity during the same test: the glucagon-insulin tolerance test.},
  author={Michael Alvarsson and Diptimayee Tripathy and Gunilla Malm and Hanieh Asgharian and Tiinamaija Tuomi and Leif Groop},
  journal={Journal of internal medicine},
  year={2008},
  volume={264 1},
  pages={
          62-71
        }
}
BACKGROUND To validate a test for independent assessment of insulin secretion and insulin sensitivity during the same occasion for metabolic studies in clinical practice, i.e. combined glucagon-stimulated C-peptide test and insulin tolerance test (GITT). SUBJECTS AND METHODS We measured C-peptide response to 0.5 mg of intravenous glucagon followed 30 min later by administration of 0.05 U kg(-1) insulin (insulin tolerance test, ITT). Ten subjects with normal glucose tolerance participated on… CONTINUE READING
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