Independent manipulation of histone H3 modifications in individual nucleosomes reveals the contributions of sister histones to transcription

Abstract

Histone tail modifications can greatly influence chromatin-associated processes. Asymmetrically modified nucleosomes exist in multiple cell types, but whether modifications on both sister histones contribute equally to chromatin dynamics remains elusive. Here, we devised a bivalent nucleosome system that allowed for the constitutive assembly of… (More)
DOI: 10.7554/eLife.30178

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