Corpus ID: 13290405

Independent induction of senescence by p16INK4a and p21CIP1 in spontaneously immortalized human fibroblasts.

@article{Vogt1998IndependentIO,
  title={Independent induction of senescence by p16INK4a and p21CIP1 in spontaneously immortalized human fibroblasts.},
  author={M. Vogt and C. Haggblom and J. Yeargin and T. Christiansen-Weber and M. Haas},
  journal={Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research},
  year={1998},
  volume={9 2},
  pages={
          139-46
        }
}

• M. Vogt, C. Haggblom, +2 authors M. Haas
• Published 1998
• Biology, Medicine
• Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research

In this work, we address the question of whether replicative senescence can be induced in immortal nontumorigenic human fibroblasts. The immortal fibroblasts used in this study were derived from two Li-Fraumeni (LF) patients who carry in their germ line one wild-type and one mutant p53 allele. Both immortal lines have lost the wtp53 allele and express no detectable p16INK4a protein, although they carry the p16INK4a gene. In contrast to immortal human fibroblasts, senescent human fibroblasts… Expand

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