Independent inactivation of MPF and cytostatic factor (Mos) upon fertilization of Xenopus eggs

@article{Watanabe1991IndependentIO,
  title={Independent inactivation of MPF and cytostatic factor (Mos) upon fertilization of Xenopus eggs},
  author={Nobumoto Watanabe and Tim Hunt and Yoji Ikawa and Noriyuki Sagata},
  journal={Nature},
  year={1991},
  volume={352},
  pages={247-248}
}
IN vertebrates, mature eggs are arrested at the second meiotic metaphase by the cytostatic factor (CSF)1, now known to be thec-mos proto-oncogene product (Mos)2, 3. Fertilization or egg activaá-tion triggers a transient increase in the cytoplasmic free calcium4, 5 and releases the meiotic arrest by inactivating maturation/mitosis-promoting factor (MPF)6, 7. CSF or Mos, which is also inactivated by the calcium transient8, 9, seems to stabilize MPF in mature eggs and CSF-injected embryos2, 6, 10… CONTINUE READING
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