Independent immunoglobulin class-switch events occurring in a single myeloma cell line.

@article{Eckhardt1985IndependentIC,
  title={Independent immunoglobulin class-switch events occurring in a single myeloma cell line.},
  author={Laurel A. Eckhardt and Barbara K. Birshtein},
  journal={Molecular and cellular biology},
  year={1985},
  volume={5 4},
  pages={856-68}
}
Five gamma 2a-producing cell lines, all derived from the gamma 2b-producing mouse myeloma MPC11, were analyzed for changes in gene structure. Also examined was a cell line (ICR9.7.1) that acts as an intermediate to some of these class switches. All six of the MPC11 variants have undergone DNA rearrangement. Rearrangement sites in the gamma 2a-producing… CONTINUE READING