Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms.

@article{Drijard1995IndependentHM,
  title={Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms.},
  author={Beno{\^i}t D{\'e}rijard and Joel Raingeaud and Tamera Barrett and I H Wu and Jiahuai Han and Richard J Ulevitch and Roger J Davis},
  journal={Science},
  year={1995},
  volume={267 5198},
  pages={682-5}
}
Mammalian mitogen-activated protein (MAP) kinases include extracellular signal-regulated protein kinase (ERK), c-Jun amino-terminal kinase (JNK), and p38 subgroups. These MAP kinase isoforms are activated by dual phosphorylation on threonine and tyrosine. Two human MAP kinase kinases (MKK3 and MKK4) were cloned that phosphorylate and activate p38 MAP kinase. These MKK isoforms did not activate the ERK subgroup of MAP kinases, but MKK4 did activate JNK. These data demonstrate that the activators… CONTINUE READING
Highly Influential
This paper has highly influenced 38 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
409 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 409 extracted citations

Similar Papers

Loading similar papers…