Independent emergence of artemisinin resistance mutations among Plasmodium falciparum in Southeast Asia.

  title={Independent emergence of artemisinin resistance mutations among Plasmodium falciparum in Southeast Asia.},
  author={Shannon L Takala-Harrison and Christopher G. Jacob and Cesar Arze and Michael P. Cummings and Joana C. Silva and Arjen Mattheus Dondorp and Mark M Fukuda and Tran Tinh Hien and Mayfong Mayxay and Harald Noedl and François H Nosten and Myat Phone Kyaw and Nguyen Thanh Thuy Nhien and Mallika Imwong and Delia R. Bethell and Youry Se and Chanthap Lon and Stuart D. Tyner and David L. Saunders and Fr{\'e}d{\'e}ric Ariey and Odile Mercereau-Puijalon and Didier M{\'e}nard and Paul Newton and Maniphone Khanthavong and Bouasy Hongvanthong and Peter Starzengruber and Hans-Peter Fuehrer and Paul T Swoboda and Wasif Ali Zafarali Khan and Aung Pyae Phyo and Myaing M Nyunt and Myat Htut Nyunt and Tyler S. Brown and Matthew J. Adams and Christopher S Pepin and Jason A. Bailey and John Tan and Michael T. Ferdig and Taane G. Clark and Olivo Miotto and Bronwyn Macinnis and Dominic P Kwiatkowski and Nicholas J White and Pascal Ringwald and Christopher V. Plowe},
  journal={The Journal of infectious diseases},
  volume={211 5},
BACKGROUND The emergence of artemisinin-resistant Plasmodium falciparum in Southeast Asia threatens malaria treatment efficacy. Mutations in a kelch protein encoded on P. falciparum chromosome 13 (K13) have been associated with resistance in vitro and in field samples from Cambodia. METHODS P. falciparum infections from artesunate efficacy trials in Bangladesh, Cambodia, Laos, Myanmar, and Vietnam were genotyped at 33 716 genome-wide single-nucleotide polymorphisms (SNPs). Linear mixed models… CONTINUE READING
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