Independent elaboration of steroid hormone signaling pathways in metazoans.


Steroid hormones regulate many physiological processes in vertebrates, nematodes, and arthropods through binding to nuclear receptors (NR), a metazoan-specific family of ligand-activated transcription factors. The main steps controlling the diversification of this family are now well-understood. In contrast, the origin and evolution of steroid ligands… (More)
DOI: 10.1073/pnas.0812138106


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