Independent effects of circulating glucose, insulin and NEFA on cardiac triacylglycerol accumulation and myocardial insulin resistance in a swine model

@article{Guzzardi2014IndependentEO,
  title={Independent effects of circulating glucose, insulin and NEFA on cardiac triacylglycerol accumulation and myocardial insulin resistance in a swine model},
  author={Maria Angela Guzzardi and Leanne Hodson and Letizia Guiducci and Elena Sanguinetti and Pietro Di Cecco and Tiziana Liistro and Cristina Vassalle and Silvia Pardini and Lucia Giorgetti and Piero Antonio Salvadori and Silvia Burchielli and Patricia Iozzo},
  journal={Diabetologia},
  year={2014},
  volume={57},
  pages={1937-1946}
}
Cardiac steatosis and myocardial insulin resistance elevate the risk of cardiac complications in obesity and diabetes. We aimed to disentangle the effects of circulating glucose, insulin and NEFA on myocardial triacylglycerol (TG) content and myocardial glucose uptake. Twenty-two pigs were stratified according to four protocols: low NEFA + low insulin (nicotinic acid), high NEFA + low insulin (fasting) and high insulin + low NEFA ± high glucose (hyperinsulinaemia–hyperglycaemia or… CONTINUE READING
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Fatty heart, cardiac damage, and inflammation

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