Independent desensitization of rat renal thick ascending limbs and collecting ducts to ADH.

@article{Dublineau1989IndependentDO,
  title={Independent desensitization of rat renal thick ascending limbs and collecting ducts to ADH.},
  author={Isabelle Dublineau and Jean-Marc Elalouf and Philippe Pradelles and Christian de Rouffignac},
  journal={The American journal of physiology},
  year={1989},
  volume={256 4 Pt 2},
  pages={F656-63}
}
Recent micropuncture studies have demonstrated that administration of high doses of 1-deamino-8-D-arginine vasopressin (dDAVP), a synthetic analogue of vasopressin (AVP), causes desensitization of the thick ascending limb to AVP but may leave unaltered the effect of this hormone on the permeability to water of the collecting duct. In the present experiments, desensitization to AVP was studied by measuring adenosine 3',5'-cyclic monophosphate (cAMP) synthesis in microdissected cortical thick… CONTINUE READING

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