Independent confirmation of a major locus for obesity on chromosome 10.

  title={Independent confirmation of a major locus for obesity on chromosome 10.},
  author={Anke Hinney and Andreas Ziegler and Frank Oeffner and C Wedewardt and Matthias Vogel and H Wulftange and Frank Geller and Karla Stuebing and Wolfgang Siegfried and Herbert Goldschmidt and Helmut Remschmidt and Johannes Hebebrand},
  journal={The Journal of clinical endocrinology and metabolism},
  volume={85 8},
Linkage results obtained in genome-wide scans for complex phenotypes require confirmation in independent samples. Recently, linkage of obesity to chromosome 10p12 with a maximal multipoint LOD score of 4.85 was reported upon use of an affected sib-pair approach including nuclear families in which the adult index case had a BMI > or = 40 kg/m2 and at least one further sibling had a BMI > or = 27 kg/m2 (Hager et al., 1998, Nat Genet 20:304-8). To attempt to replicate this linkage finding we… CONTINUE READING
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