Independent and interdependent immunoregulatory effects of IL-27, IFN-β, and IL-10 in the suppression of human Th17 cells and murine experimental autoimmune encephalomyelitis.

@article{Fitzgerald2013IndependentAI,
  title={Independent and interdependent immunoregulatory effects of IL-27, IFN-β, and IL-10 in the suppression of human Th17 cells and murine experimental autoimmune encephalomyelitis.},
  author={Denise C. Fitzgerald and Zo{\"e} D. Fonseca-Kelly and Melissa L. Cullimore and Pegah Safabakhsh and Christiaan J. M. Saris and Guang-xian Zhang and Abdolmohamad M. Rostami},
  journal={Journal of immunology},
  year={2013},
  volume={190 7},
  pages={3225-34}
}
IFN-β, IL-27, and IL-10 have been shown to exert a range of similar immunoregulatory effects in murine and human experimental systems, particularly in Th1- and Th17-mediated models of autoimmune inflammatory disease. In this study we sought to translate some of our previous findings in murine systems to human in vitro models and delineate the interdependence of these different cytokines in their immunoregulatory effects. We demonstrate that human IL-27 upregulates IL-10 in T cell-activated PBMC… CONTINUE READING

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