Independent and interactive effects of blood pressure and cardiac function on brain volume and white matter hyperintensities in heart failure.

@article{Alosco2013IndependentAI,
  title={Independent and interactive effects of blood pressure and cardiac function on brain volume and white matter hyperintensities in heart failure.},
  author={Michael L. Alosco and Adam M. Brickman and Mary Beth Spitznagel and Erica Y. Griffith and Atul Narkhede and Naftali Raz and Ronald A. Cohen and Lawrence H. Sweet and Joel Hughes and Jim Rosneck and John J. Gunstad},
  journal={Journal of the American Society of Hypertension : JASH},
  year={2013},
  volume={7 5},
  pages={336-43}
}
BACKGROUND Reduced systemic perfusion and comorbid medical conditions are key contributors to adverse brain changes in heart failure (HF). Hypertension, the most common co-occurring condition in HF, accelerates brain atrophy in aging populations. However, the independent and interactive effects of blood pressure and systemic perfusion on brain structure in HF have yet to be investigated. METHODS Forty-eight older adults with HF underwent impedance cardiography to assess current systolic blood… CONTINUE READING

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