Independent and cooperative activation of chromosomal c-fos promoter by STAT3.

@article{Yang2003IndependentAC,
  title={Independent and cooperative activation of chromosomal c-fos promoter by STAT3.},
  author={Edward Yang and Lorena Lerner and Daniel Besser and J. E. Darnell},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 18},
  pages={15794-9}
}
The c-fos gene was one of the earliest vertebrate genes shown to be transcriptionally induced by growth factors. Intensive study of the promoter of c-fos (-325 to -80) by transient or permanent transfections of synthetic DNA constructs has repeatedly shown the importance of several sequence elements and the resident nuclear proteins that bind them (e.g. ternary complex factor/ELK1; serum response factor, cAMP response element-binding protein/amino-terminal fragment/AP-1). However these studies… CONTINUE READING