Independent and combined effects of prolonged inhaled nitric oxide and oxygen on lung inflammation in newborn piglets.

@article{Ekekezie2000IndependentAC,
  title={Independent and combined effects of prolonged inhaled nitric oxide and oxygen on lung inflammation in newborn piglets.},
  author={Ikechukwu I. Ekekezie and Donald W. Thibeault and David Zwick and Mohammad H Rezaiekhaligh and Sherry M. Mabry and Ryan E Morgan and Michael I. Norberg and William E. Truog},
  journal={Biology of the neonate},
  year={2000},
  volume={77 1},
  pages={37-44}
}
Clinical use of nitric oxide (NO) is usually in conjunction with high oxygen concentrations, the effects of which may include lung neutrophil accumulation, apoptosis and upregulation of antioxidant enzyme activity. To define the effects of NO on neutrophils from young piglets and its relationship to lung neutrophil dynamics during hyperoxia we exposed thirty piglets to room air (RA), RA+NO (50 ppm NO), O2 (FiO2> or =0.96) or O2+NO for 5 days. Ten additional animals breathed RA+NO or O2+NO, then… CONTINUE READING
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