Independent and combined effects of ethanol self-administration and nicotine treatment on hepatic CYP2E1 in African green monkeys.

@article{Ferguson2011IndependentAC,
  title={Independent and combined effects of ethanol self-administration and nicotine treatment on hepatic CYP2E1 in African green monkeys.},
  author={Charmaine S. Ferguson and Sharon Miksys and Roberta M Palmour and Rachel F. Tyndale},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2011},
  volume={39 12},
  pages={
          2233-41
        }
}
Cytochrome P450 2E1 metabolizes ethanol and also bioactivates many toxins and procarcinogens. Elevated levels of hepatic CYP2E1 are associated with an increased susceptibility to chemical toxicity and carcinogenesis. This study investigated the induction of hepatic CYP2E1 by ethanol and nicotine, alone and in combination, in a nonhuman primate model. Monkeys that self-administered ethanol and that received subcutaneous injections of nicotine (0.5 mg/kg b.i.d.), alone and in combination, were… CONTINUE READING

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