Independent Modes of Natural Killing Distinguished in Mice Lacking Lag3

@article{Miyazaki1996IndependentMO,
  title={Independent Modes of Natural Killing Distinguished in Mice Lacking Lag3},
  author={Toru Miyazaki and Andrée Dierich and Christophe Benoist and Diane Mathis},
  journal={Science},
  year={1996},
  volume={272},
  pages={405 - 408}
}
The LAG3 protein has several features in common with CD4, suggesting that it may be important in controlling T cell reactivity. However, mice with a Lag3 null mutation have now been shown to exhibit a defect in the natural killer cell, rather than the T cell, compartment. Killing of certain tumor targets by natural killer cells from these mice was inhibited or even abolished, whereas lysis of cells displaying major histocompatibility complex class I disparities remained intact. It appears that… Expand
LAG-3 is not responsible for selecting T helper cells in CD4-deficient mice.
TLDR
LAG-3 thus does not explain class II-restricted lymphocyte selection and function in the absence of CD4, strengthening the idea that these phenomena can occur independently of co-receptor signalling. Expand
LAG-3 Confers a Competitive Disadvantage upon Antiviral CD8+ T Cell Responses
TLDR
The results indicate that LAG-3 expression by CD8+ T cells inhibits their competitive fitness and results in a slightly reduced rate of cell division in comparison with L AG-3–deficient cells, and this cell-intrinsic effect was consistent across both acute and chronic virus infections. Expand
LAG-3: a regulator of T-cell and DC responses and its use in therapeutic vaccination.
  • F. Triebel
  • Biology, Medicine
  • Trends in immunology
  • 2003
TLDR
Recent studies in mice have reconciled previous interpretations and clearly show that, as in human cells, LAG-3 negatively regulates T-cell function and homeostasis. Expand
Combined natural killer cell and dendritic cell functional deficiency in KARAP/DAP12 loss-of-function mutant mice.
TLDR
It is reported that knockin mice bearing a nonfunctional KARAP/DAP12 ITAM present altered innate immune responses, emphasizing the nonredundancy of these ITAM-bearing polypeptides in hematopoietic cells. Expand
Role of LAG-3 in regulatory T cells.
TLDR
It is proposed that LAG-3 marks regulatory T cell populations and contributes to their suppressor activity, which reduces their proliferative capacity and confers on them suppressionor activity toward effector T cells. Expand
Missing self by heterogeneous natural killer cells
TLDR
It is proposed that acid treatment of tumour cells enhances their lysis susceptibility by making them additionally susceptible to type II NK cells, rather than enhancing their killing by type I NK cells. Expand
LAG-3 Inhibitory Receptor Expression Identifies Immunosuppressive Natural Regulatory Plasma Cells
TLDR
A novel subset of natural regulatory plasma cells characterized by the expression of LAG‐3 that develops at steady state independently of microbiota, and respond to innate stimulation by producing immunosuppressive IL‐10 is identified. Expand
Phenotypic analysis of the murine CD4‐related glycoprotein, CD223 (LAG‐3)
TLDR
It is shown that mRNA expression is restricted to the thymic medulla, splenic red pulp and sparse cells in the adult brain cortex, and a new monoclonal antibody (mAb) that recognizes an epitope in the D2 domain should greatly assist in the elucidation of CD223 function. Expand
Normal development but differentially altered proliferative responses of lymphocytes in mice lacking CD81
TLDR
Though CD81 is not essential for normal T‐ and conventional B‐cell development, it plays key roles in controlling lymphocyte homeostasis by regulating lymphocyte proliferation in distinct manners, dependent on the context of stimulation. Expand
Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape.
TLDR
A strong synergy between the PD-1 and LAG-3 inhibitory pathways in tolerance to both self and tumor antigens is defined and it is argued strongly that dual blockade of these molecules represents a promising combinatorial strategy for cancer. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 42 REFERENCES
Altered natural killer cell repertoire in Tap-1 mutant mice.
TLDR
The hypothesis that class I molecules of the MHC influence the sensitivity of target cells to lysis by NK cells, as well as the development of the NK cell repertoire, is supported. Expand
Lysis of a lung carcinoma by poly I:C-induced natural killer cells is independent of the expression of class I histocompatibility antigens.
TLDR
Cells from the line 1 murine carcinoma express little if any H-2d when grown in normal medium, and transfection into line 1 leads to a constitutive and DMSO-inducible expression of H- 2Dp at functionally significant levels, but this expression appears to have no influence on NK cytolytic susceptibility. Expand
Mouse NKR-P1. A family of genes selectively coexpressed in adherent lymphokine-activated killer cells.
TLDR
This work cloned its mouse homologue by cross-hybridization of the rat gene to a cDNA library generated from highly purified mouse lymphokine-activated NK cells and found that three messages, differing in size and sequence and encoded by different genes, are specifically cotranscribed in mouse NK cells. Expand
Natural killer cell receptors.
  • W. Yokoyama
  • Biology, Medicine
  • Current opinion in immunology
  • 1995
TLDR
Recognition of susceptible targets and activation now appear to be mediated by a natural killer cell receptor that binds carbohydrate determinants on target cells and initiates target lysis. Expand
Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells.
TLDR
Mouse chimeras derived from embryonic stem cells with a disrupted beta 2M gene transmitted the inactivated gene to their progeny and these animals are grossly deficient in CD4- CD8+ T cells, which normally mediate cytotoxic T cell function. Expand
The Ly-49 and NKR-P1 gene families encoding lectin-like receptors on natural killer cells: the NK gene complex.
TLDR
Target cell susceptibility to natural killing may be dependent upon specific ligand-receptor interaction with these activating or inhibitory NKC-encoded molecules. Expand
Natural killer cell receptors specific for major histocompatibility complex class I molecules.
  • W. Yokoyama
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1995
TLDR
Detailed analysis of the Ly-49family members should improve understanding ofNKcell specificity, and substantial progress has been made on the function ofative inhibitory receptors specific forHLAclass I molecules. Expand
Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice.
TLDR
Infection of CD4-null mice with Leishmania has revealed a population of functional helper T cells that develops despite the absence ofCD4, indicating that T lymphocyte lineage commitment and peripheral function need not depend on the function of CD 4. Expand
Natural killer cell receptors: The offs and ons of NK cell recognition
TLDR
Recent results suggest that target cell lysis by NK cells is regulated by a balance between specific activating and inhibitory receptors, and class I molecules allow specific recognition and lysis of infected cells. Expand
Recognition of major histocompatibility complex class I antigens by natural killer cells
  • G. Trinchieri
  • Biology, Medicine
  • The Journal of experimental medicine
  • 1994
TLDR
It is shown that NK cells were the effector cells responsible for the rejection of parental bone marrow grafts in irradiated F1 mice (hematopoietic hybrid resistance) indicating a genetic specificity in NK cell action. Expand
...
1
2
3
4
5
...