Independent Manner − α to Multiple Chemotherapy Agents in an IAP-Dependent but TNF-Small Cell Lung Cancers − SMAC Mimetic ( JP 1201 ) Sensitizes Non

@inproceedings{Greer2011IndependentM,
  title={Independent Manner − α to Multiple Chemotherapy Agents in an IAP-Dependent but TNF-Small Cell Lung Cancers − SMAC Mimetic ( JP 1201 ) Sensitizes Non},
  author={Rachel M. Greer and Michael Peyton and Jill Everland Larsen and Luc Girard and Yang Xie and Adi F. Gazdar and Patrick G Harran and Lai Wang and Rolf A Brekken and Xiaodong Wang and John D. Minna},
  year={2011}
}
Inhibitors of apoptosis proteins (IAP) are key regulators of apoptosis and are inhibited by the second mitocondrial activator of caspases (SMAC). Previously, a small subset of TNF-a–expressing non–small cell lung cancers (NSCLC) was found to be sensitive to SMAC mimetics alone. In this study, we determined if a SMAC mimetic (JP1201) could sensitize nonresponsive NSCLC cell lines to standard chemotherapy. We found that JP1201 sensitized NSCLCs to doxorubicin, erlotinib, gemcitabine, paclitaxel… CONTINUE READING

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