Independent Correlation Between Ki67 Index and Circulating Tumor Cells in the Diagnosis of Colorectal Cancer.

@article{Yang2017IndependentCB,
  title={Independent Correlation Between Ki67 Index and Circulating Tumor Cells in the Diagnosis of Colorectal Cancer.},
  author={Yingchi Yang and Jun Li and Lan Shu Jin and Dong Wang and Jinghui Zhang and Jin Wang and Xiaomu Zhao and Guocong Wu and Hongwei Yao and Zhongtao Zhang},
  journal={Anticancer research},
  year={2017},
  volume={37 8},
  pages={
          4693-4700
        }
}
BACKGROUND The Ki67 index is a biomarker of proliferation, while the circulating tumor cell (CTC) count acts as a metastasis-related biomarker. In this study, we analyzed the potential value of CTC count and Ki67 index in diagnosis of colorectal cancer (CRC). MATERIALS AND METHODS A total of 105 patients with CRC undergoing surgery were included in the study. Isolation and identification of CTCs were performed by negative enrichment and immuno-fluorescence in situ hybridization, respectively… CONTINUE READING