Independence of substituent contributions to the transport of small-molecule permeants in lipid bilayer

@article{Mayer2008IndependenceOS,
  title={Independence of substituent contributions to the transport of small-molecule permeants in lipid bilayer},
  author={P. T. Mayer and Tian-xiang Xiang and Bradley D. Anderson},
  journal={AAPS PharmSci},
  year={2008},
  volume={2},
  pages={40-52}
}
  • P. T. Mayer, Tian-xiang Xiang, Bradley D. Anderson
  • Published 2008
  • Chemistry, Medicine
  • AAPS PharmSci
  • Purpose: To explore the independence of functional group contributions to permeability of nonelectrolytes across egg lecithin bilayers. Methods. The transport rates were measured of a series of α-substituted p-methylhippuric acids (-H,-Cl,-OCH3,-CN,-OH,-COOH, and-CONH2) across egg lecithin lipid bilayers, in the form of large unilamellar vesicles (LUVs) at 25EC. Intrinsic permeability coefficients (PHA) were calculated from apparent permeability coefficients (Papp) measured as a function of pH… CONTINUE READING
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