Independence of estrogen-induced pituitary proliferation on local IGF-I mRNA and EGF mRNA expression. Modifying effects of tamoxifen and terguride.

@article{Hna1998IndependenceOE,
  title={Independence of estrogen-induced pituitary proliferation on local IGF-I mRNA and EGF mRNA expression. Modifying effects of tamoxifen and terguride.},
  author={V{\'a}clav H{\'a}na and Martin Haluz{\'i}k and Vratislav Schreiber},
  journal={Physiological research},
  year={1998},
  volume={47 2},
  pages={125-31}
}
Pituitary hyperplasia as well as proliferation of the endometrium are typical responses to estrogen administration in rodents. Both insulin-like growth factor-I (IGF-I) and epidermal growth factor (EGF) have been implicated as paracrine mediators and amplifiers of estrogen action in the rodent uterus. The auto/paracrine role of IGF-I, EGF, their receptors… CONTINUE READING